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Normal internal architecture: Child Staining patterns: Coarser than in adults Neonate: 1 week of age Infant: 1 year of age`GENERAL INDICATIONS FOR MUSCLE BIOPSIES Presence of some evidence of muscle disease Weakness Muscle symptoms: Discomfort; Cramps; Fatigue with activity (r/o …%Type II atrophy: Pathology Type II (Dark at pH 9.4) Muscle fibers Small: Reduced cross-sectional area\ Shape Adult: Angular or Elongated Childhood: Polygonal or Round Early changes*Motor neuropathy-Motor neuron syndromes Multifocal motor neuropathy (MMN) Anti-GM1 antibodies: Indications Only use laboratories that find IgM anti-GM1 antibodies in > 40% of …/Diagnostic (Molecular) testing: When a pattern of disease and its tissue localization are identified other laboratory testing can be employed to make a specific diagnosis, guide co~Sensory Neuronopathy: Small fiber 11 Onset Age: 18 to 64 years Pain & Dysesthesias Hands or Face in 40% Course: Days to Years Clinical Strength: Normal Sensory Loss distribution No,The Park-Reeves Syringomyelia Research Consortium is a multi-institutional North American research effort founded to improve the medical and surgical care of children with syringom